• Health and Nutrition

Drugs and Molecules for Living Systems (M2SV)

Research unit - U 1177

Description

The mission of our unit is to design and synthesize drug candidates presenting an innovative mode of action, aiming to offer significant therapeutic progress in indications where medical need is unmet. This interdisciplinary molecular invention is based on the latest findings on the mechanisms of infectious, metabolic and cancer diseases. Beyond the therapeutic objective, molecules also serve as valuable tools that help biologists better understand how cells and living organisms function and verify that the proposed hypotheses for the treatment of diseases are relevant. The team’s researchers are working on antibiotic resistance, viral infections (COVID-19), type 2 diabetes, NASH, some forms of cancer and autoimmune diseases.

Contacts

Informations

3 rue du Professeur Laguesse
Faculté de Pharmacie de Lille, BP83
59006 LILLE

https://www.deprezlab.fr/

Expertises

Skills

• Drug design
• Synthesis of drug candidates
• Molecular invention
• Mechanisms of infectious, metabolic and cancer diseases
• Modelling in silico
• Medicinal chemistry
• High throughput molecular screening
• Pharmacokinetics

Example(s) of projects

• ANR EFFORT - Development of bacterial efflux pump inhibitors
• ANR ERAPIMM - development of ERAP inhibitors as a new approach to treat autoimmune and autoinflammatory diseases
• ANR Detonator - Development of new anti-fungal fluoroquinolones

Example(s) of publications

• Plé C. et al. Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nature Communications, 2022
• Kraupner N. et al. Identification of indole-based activators of insulin degrading enzyme. European Journal of Medicinal Chemistry, 2021
• Deprez B. et al. Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry. Molecules, 2021

Collaborations/Partners/Scientific clients

Several national and international collaborations:

National:
Necker Institute

International:
University of Chicago (USA), Birdshot Uveitis Society (UK), Demokritos Center (GR)

Services offers

Applications sectors

  • Health / wellness
  • Education / Training
  • Science / Research

Services provided

• High throughput and high content screening
• Test development and compound screening
• ADME/PK studies
• Physico-chemical (in vitro) properties: kinetic solubility, thermodynamic solubility, lipophilia, chemical stability
• Virtual screening
• Chemical synthesis
• Protein-protein interaction studies

Training offers

Master’s course - Design, Synthesis, Evaluation and Selection of Active Principles

Consulting services

We provide consulting services on all our skills

Equipments

Biological materials

• Chemo - 200,000 molecules
• siRNAtheque

Ecosystem

Affiliated institutions / organisations

Inserm
University of Lille
Institut Pasteur de Lille

Groups/Networks/Federations

GDR ChemBioScreen

Doctoral schools

Regional strategic areas of activity

  • Health and Nutrition
    • Food ingredients
    • New therapeutic approaches

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Thematics

Current thematics

  • Health and Nutrition
    • Food ingredients
    • New therapeutic approaches
Title

Current content

Drugs and Molecules for Living Systems
Type

Current content

Research unit
Description

Current content

The mission of our unit is to design and synthesize drug candidates presenting an innovative mode of action, aiming to offer significant therapeutic progress in indications where medical need is unmet. This interdisciplinary molecular invention is based on the latest findings on the mechanisms of infectious, metabolic and cancer diseases. Beyond the therapeutic objective, molecules also serve as valuable tools that help biologists better understand how cells and living organisms function and verify that the proposed hypotheses for the treatment of diseases are relevant. The team’s researchers are working on antibiotic resistance, viral infections (COVID-19), type 2 diabetes, NASH, some forms of cancer and autoimmune diseases.
Contact informations
Contact

Current content

URL

Current content

https://www.deprezlab.fr/

Address

Current content

3 rue du Professeur Laguesse
Faculté de Pharmacie de Lille, BP83
59006 LILLE
Keywords

Current content

Drugs, Molecules, Synthesis, Modeling in silico, Active ingredients, Medicinal chemistry, Chemobiology, Antibiotic resistance, Inhibitors, Chemical probes
Our search domains
Skills

Current content

• Drug design • Synthesis of drug candidates • Molecular invention • Mechanisms of infectious, metabolic and cancer diseases • Modelling in silico • Medicinal chemistry • High throughput molecular screening • Pharmacokinetics
Workforce

Current content

Nombre de chercheurs :
Nombre de doctorants :
Nombre de personnel d'appui à la recherche :
Effectif total :
Example(s) of projects

Current content

• ANR EFFORT - Development of bacterial efflux pump inhibitors • ANR ERAPIMM - development of ERAP inhibitors as a new approach to treat autoimmune and autoinflammatory diseases • ANR Detonator - Development of new anti-fungal fluoroquinolones
Example(s) of publications

Current content

• Plé C. et al. Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nature Communications, 2022 • Kraupner N. et al. Identification of indole-based activators of insulin degrading enzyme. European Journal of Medicinal Chemistry, 2021 • Deprez B. et al. Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry. Molecules, 2021
Collaborations/Partners/Scientific clients

Current content

Several national and international collaborations: National: Necker Institute International: University of Chicago (USA), Birdshot Uveitis Society (UK), Demokritos Center (GR)
Collaborations/Partners/Private Clients

Current content

Services offers
Training offers

Current content

Master’s course - Design, Synthesis, Evaluation and Selection of Active Principles
Services offers

Current content

• High throughput and high content screening • Test development and compound screening • ADME/PK studies • Physico-chemical (in vitro) properties: kinetic solubility, thermodynamic solubility, lipophilia, chemical stability • Virtual screening • Chemical synthesis • Protein-protein interaction studies
Consulting services

Current content

We provide consulting services on all our skills
Equipments
Equipements spécifiques

Current content

Ecosystem
Affiliated institutions / organisations

Current content

  • Inserm
  • University of Lille
  • Institut Pasteur de Lille
Établissement(s) partenaire(s)

Current content

Unit(s) of attachment

Current content

Groups/Networks/Federations

Current content

GDR ChemBioScreen
Doctoral schools

Current content

Equipex/EquipEx+/ESR

Current content

Competitive cluster

Current content

Regional strategic areas of activity

Current content

  • Health and Nutrition
  • Food ingredients
  • New therapeutic approaches
Personal informations
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