• Health and Nutrition

Drugs and Molecules for Living Systems (M2SV)

Research unit - U 1177


The mission of our unit is to design and synthesize drug candidates presenting an innovative mode of action, aiming to offer significant therapeutic progress in indications where medical need is unmet. This interdisciplinary molecular invention is based on the latest findings on the mechanisms of infectious, metabolic and cancer diseases. Beyond the therapeutic objective, molecules also serve as valuable tools that help biologists better understand how cells and living organisms function and verify that the proposed hypotheses for the treatment of diseases are relevant. The team’s researchers are working on antibiotic resistance, viral infections (COVID-19), type 2 diabetes, NASH, some forms of cancer and autoimmune diseases.



3 rue du Professeur Laguesse
Faculté de Pharmacie de Lille, BP83
59006 LILLE




• Drug design
• Synthesis of drug candidates
• Molecular invention
• Mechanisms of infectious, metabolic and cancer diseases
• Modelling in silico
• Medicinal chemistry
• High throughput molecular screening
• Pharmacokinetics

Example(s) of projects

• ANR EFFORT - Development of bacterial efflux pump inhibitors
• ANR ERAPIMM - development of ERAP inhibitors as a new approach to treat autoimmune and autoinflammatory diseases
• ANR Detonator - Development of new anti-fungal fluoroquinolones

Example(s) of publications

• Plé C. et al. Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nature Communications, 2022
• Kraupner N. et al. Identification of indole-based activators of insulin degrading enzyme. European Journal of Medicinal Chemistry, 2021
• Deprez B. et al. Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry. Molecules, 2021

Collaborations/Partners/Scientific clients

Several national and international collaborations:

Necker Institute

University of Chicago (USA), Birdshot Uveitis Society (UK), Demokritos Center (GR)

Services offers

Applications sectors

  • Education / Training
  • Health / wellness
  • Science / Research

Services provided

• High throughput and high content screening
• Test development and compound screening
• ADME/PK studies
• Physico-chemical (in vitro) properties: kinetic solubility, thermodynamic solubility, lipophilia, chemical stability
• Virtual screening
• Chemical synthesis
• Protein-protein interaction studies

Training offers

Master’s course - Design, Synthesis, Evaluation and Selection of Active Principles

Consulting services

We provide consulting services on all our skills


Biological materials

• Chemo - 200,000 molecules
• siRNAtheque


Affiliated institutions / organisations


Doctoral schools

Regional strategic areas of activity

  • Health and Nutrition
    • Food ingredients
    • New therapeutic approaches