• Health and Nutrition

Advanced Drug Delivery Systems (ADDS)

Research unit - U1008


Our laboratory is interested in the field of controlled drug delivery. We are a multidisciplinary team with expertise in pharmacy, medicine, dentistry, materials science, mathematics and biology. We conduct interdisciplinary and translational research in the field of controlled drug delivery systems from the development of formulations, the study of their manufacturing processes, their in vitro and in vivo characterizations with a focus on mathematical modeling of the release process for the establishment of in vitro - in vivo correlation. Depending on the field, this activity is oriented towards clinical research (vascular prostheses, ENT) or towards industrial research (e.g.: development of innovative coating systems). We are open to all academic and industrial collaborations and propose services in line with our expertise.


  • Juergen Siepmann


3, Rue du Professeur Laguesse
Faculté de Pharmacie, Campus Santé, Université de Lille
59006 LILLE


Advanced Drug Delivery Systems


Effectif total : 49

Personnel de recherche : 27

Personnel d'appui à la recherche : 7



• Controlled release delivery systems
• Advanced delivery systems for active ingredients
• Mechanisms of mass transport
• Mathematical modeling of the release process
• In-silico simulations
• Innovative coating systems
• Innovative biomaterials
• Controlled release implants
• Controlled release of active ingredients
• Release mechanisms
• Tablets
• Coated granules
• In-situ forming implants to treat periodontitis
• Cochlear implants
• Active stents
• Bone substitutes

Example(s) of projects

• Aquacoat ARC® (an innovative polymer film coating that can be used to prepare solid oral controlled release dosage forms, e.g. tablets or capsules) was commercialized in 2013.

• Development and commercialization in 2021 of new types of filtering and decontaminating masks that not only trap viruses, but also deactivate them. They reduce the viral load by 99.9% in less than 5 minutes. The process, called CIDALTEX®, is used today by the French company Bioserenity to manufacture these virucidal masks. 🡭

Example(s) of publications

• Chai, F., Maton, M., Degoutin, S., Vermet, G., Simon, N., Rousseaux, C., Martel, B., Blanchemain, N. In vivo evaluation of post-operative pain reduction on rat model after implantation of intraperitoneal PET meshes functionalised with cyclodextrins and loaded with ropivacaine. Biomaterials, 192, pp. 260-270, 2019. 🡭

• Fahier, J; Muschert, S; Fayard, B; Velghe, C; Byrne, G; Doucet, J; Siepmann, F; Siepmann, J. Importance of air bubbles in the core of coated pellets: Synchrotron X-ray microtomography allows for new insights. Journal of Controlled Release 237, 125-137, 2016.🡭

• Gasmi, H; Danede, F; Siepmann, J; Siepmann, F. Does PLGA microparticle swelling control drug release? New insight based on single particle swelling studies. Journal of Controlled Release 213, 120-127, 2015.🡭

• Karrout, Y; Dubuquoy, L; Piveteau, C; Siepmann, F; Moussa, E; Wils, D; Beghyn, T; Neut, C; Flament, MP; Guerin-Deremaux, L; Dubreuil, L; Deprez, B; Desreumaux, P; Siepmann, J. In vivo efficacy of microbiota-sensitive coatings for colon targeting: A promising tool for IBD therapy. Journal of Controlled Release 197, 121-130, 2015.🡭

• Velghe, C; Rosiaux, Y; Marchaud, D; Siepmann, J; Siepmann, F. In-silico simulation of niacin release from lipid tablets: Theoretical predictions and independent experiments. Journal of Controlled Release 175, 63-71, 2014.🡭

Collaborations/Partners/Scientific clients

National :
ENSAIT, Université de Valenciennes

International :
Martin-Luther-Universität Halle-Wittenberg (Germany), Ludwig-Maximilians-Universitaet Muenchen (Germany), Universitaet Duesseldorf (Germany), Universitaet Halle (Germany), University of Cambridge (UK), University of Copenhagen (Denmark), University of Copenhagen (Denmark), University of Gent (Belgium), University of Iceland (Iceland), University of London (UK), University of Lund (Sweden), University of Sydney (Australia), University of Texas (USA)

Collaborations/Partners/Private Clients

Cousin Biotech (laboratoire commun COUS’UMain)

Services offers

Applications sectors

  • Health / wellness
  • Education / Training
  • Science / Research

Services provided

• Design and preparation of innovative advanced drug delivery systems allowing or improving therapeutic treatments
• Characterization of new in vitro and in vivo prototypes (animals and humans)
• Identification of the dominant physicochemical/biological phenomena controlling drug release
• Development of mechanically realistic mathematical theories to facilitate device optimization via in-silico simulations, e.g. reduce the number of in vitro and in vivo studies required

Consulting services

We provide consulting services related to all our areas of expertise.

Offres technologiques

  • STEELJAW: A new conception of Temporo Mandibular Joint (TMJ) and the method to assemble it
    New conception of Temporo Mandibular Joint (TMJ) and the method to assemble it The glenoid insert can be easily fixed and release from the glenoid support, by a manual action on a tab, in order to facilitate it’s precise adjustment or it’s change to perfectly match with the condylar part. Read more.


We posess state-of-the-art equipment and analytical tools related to our core expertise: 3D printer, autoclave, climate chamber, drum coater, extruder, fluorometer, freeze dryer, helium pycnometer, hot melt extruder, hot stage microscope, HPLC/GPC, HPLC-UV, diffractometer, mDSC, optical image analysis system, optical microscope, ball mill, rheometer, tabletting machines, spheronizer, spray dryers, stereomicroscopes, texture analyzers, UV spectrophotometers...

Seethe detailed list of equipment here: http://u1008. univ-lille2.fr/equipment.html


Affiliated institutions / organisations


Doctoral schools

Regional strategic areas of activity

  • Health and Nutrition