• Health and Nutrition

Cell Plasticity and Cancer (CANTHER)

Research team - UMR9020 CNRS – UMR1277 Inserm

Description

The main objective of our team is to decipher the molecular mechanisms of cancer cell plasticity governing resistance to therapies for breast cancer and pediatric glioma. Our project combines proteomics and epigenomics, the study of the reprogramming of cancer stem cells, models of transgenic mice in vivo and zebrafish, artificial intelligence in oncogenomics and cellular regulation networks. In collaboration with physicists, we have developed microsystems (MEMS) to characterize the mechanical properties of individual cells, as well as microfluidic systems for studying the plasticity and disseminating capabilities of cells. Through this fundamental and translational research, our ultimate goal is to discover new markers and/or therapeutic targets, and to propose innovative therapeutic strategies for the treatment of breast cancer and child glioma.

Contacts

  • Xuefen Le Bourhis
    Contact

Informations

1 Place de Verdun, Bâtiment Cancer
Université de Lille
59045 LILLE

http://canther.fr/fr/equipe-plasticite-cellulaire-et-cancer/

Expertises

Skills

• Breast cancer
• Breast cancer metastases
• Pediatric gliomas
• Cell plasticity
• Resistance to treatment
• Mechanisms of resistance to therapy and metastasis of breast cancer

Example(s) of publications

All our publications can be found here : 🡭

Services offers

Applications sectors

  • Science / Research

Consulting services

We provide consulting services on all our skills

Ecosystem

Affiliated institutions / organisations

CHU de Lille
Inserm
University of Lille
CNRS
Centre Oscar Lambret
Institut Pasteur de Lille

Unit(s) of attachment

Doctoral schools

Regional strategic areas of activity

  • Health and Nutrition

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Thematics

Current thematics

  • Health and Nutrition
Title

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Cell Plasticity and Cancer
Type

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Research team
Description

Current content

The main objective of our team is to decipher the molecular mechanisms of cancer cell plasticity governing resistance to therapies for breast cancer and pediatric glioma. Our project combines proteomics and epigenomics, the study of the reprogramming of cancer stem cells, models of transgenic mice in vivo and zebrafish, artificial intelligence in oncogenomics and cellular regulation networks. In collaboration with physicists, we have developed microsystems (MEMS) to characterize the mechanical properties of individual cells, as well as microfluidic systems for studying the plasticity and disseminating capabilities of cells. Through this fundamental and translational research, our ultimate goal is to discover new markers and/or therapeutic targets, and to propose innovative therapeutic strategies for the treatment of breast cancer and child glioma.
Contact informations
Contact

Current content

Contact name Email phone number
LE BOURHIS Xuefen xuefen.le-bourhis@univ-lille.fr (+33) 6 28 39 47 24
URL

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http://canther.fr/fr/equipe-plasticite-cellulaire-et-cancer/

Address

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1 Place de Verdun, Bâtiment Cancer
Université de Lille
59045 LILLE
Keywords

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Breast cancer, cell plasticity, tumor resistance, metastasis, microenvironment, signaling, epigenetics, gene instability, stem cells
Our search domains
Skills

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• Breast cancer • Breast cancer metastases • Pediatric gliomas • Cell plasticity • Resistance to treatment • Mechanisms of resistance to therapy and metastasis of breast cancer
Workforce

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Nombre de chercheurs :
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Example(s) of projects

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Example(s) of publications

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All our publications can be found here : 🡭
Collaborations/Partners/Scientific clients

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Collaborations/Partners/Private Clients

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Services offers
Training offers

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Services offers

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Consulting services

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We provide consulting services on all our skills
Equipments
Equipements spécifiques

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Ecosystem
Affiliated institutions / organisations

Current content

  • CHU de Lille
  • Inserm
  • University of Lille
  • CNRS
  • Centre Oscar Lambret
  • Institut Pasteur de Lille
Établissement(s) partenaire(s)

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Unit(s) of attachment

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  • Cancer Heterogeneity, Plasticity and Resistance to Therapies
Groups/Networks/Federations

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Doctoral schools

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Equipex/EquipEx+/ESR

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Competitive cluster

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Regional strategic areas of activity

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  • Health and Nutrition
Personal informations
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