• Health and Nutrition

Center for Infection & Immunity of Lille (CIIL)

Research unit - UMR 9017 - U 1019

Description

The Center for Infection & Immunity of Lille (CIIL) develops research projects on the molecular and cellular mechanisms of infectious and chronic inflammatory diseases with the aim to apply this knowledge to the development of improved diagnostics, vaccines and therapeutics. To achieve these goals, our Center gathers complementary expertise, covering a wide range of disciplines from epidemiology, molecular and cellular virology, bacteriology and parasitology, to the immunological basis of infectious and non-infectious diseases and translation into clinical applications. The CIIL studies bacterial, viral and parasitic diseases and the immune reaction against these infections as well as related immune dysfunctions of non-infectious diseases such as allergic asthma and chronic obstructive pulmonary disease (COPD). We also work on opportunistic infections in the context of cystic fibrosis which is the most frequent human genetic disease. The major infectious diseases that we investigate are tuberculosis, pneumococcal pneumonia, whooping cough, plague, hepatitis C and E, influenza, Middle East respiratory syndrome (MERS), COVID-19, malaria, schistosomiasis, toxoplasmosis, cryptosporidiosis and blastocystosis.

Contacts

  • Jean Dubuisson
    Directeur

Informations

1 Rue du Professeur Calmette
Campus de l’Institut Pasteur de Lille, Université de Lille
59000 LILLE

https://www.ciil.fr/

Center for Infection & Immunity of Lille

Effectif

Effectif total : 221

Personnel de recherche : 125

Personnel d'appui à la recherche : 31

Expertises

Skills

• Epidemiology
• Molecular and cellular virology
• Bacteriology and parasitology
• Immunological basis of infectious and non-infectious diseases
• Chemical Genomics of Intracellular Mycobacteria
• Opportunist Infection, Immunity, Environment & Lung Diseases
• Chemical Biology of Antibiotics
• Biology of Apicomplexan Parasites
• Cellular Microbiology And Physics Of Infection
• Chemical Biology of Flatworms
• Research on Mycobacteria and Bordetella
• Tropical Biome & Immuno-Pathophysiology
• Plague & Yersinia pestis
• Bacteria, Antibiotics and Immunity
• Influenza, Immunity and Metabolism
• Pulmonary Immunity
• Ecology & Physiopathology of Intestinal Protozoa

Example(s) of projects

• ERC: ANTIBIOCLICKS
• European programs: ERA4TB, FAIR, PHYS2BIOMED
• Investments for the Future programme: LABEX PARAFRAP, IHU RESPIRE
• CPER RESISToMICS

Example(s) of publications

• TgAP2IX-5 is a key transcriptional regulator of the asexual cell cycle division in Toxoplasma gondii. Khelifa AS, Guillen Sanchez C, Lesage KM, Huot L, Mouveaux T, Pericard P, Barois N, Touzet H, Marot G, Roger E, Gissot M. Nat Commun. 2021 Jan 7;12(1):116. 🡭
• A cysteine selenosulfide redox switch for protein chemical synthesis. Diemer V, Ollivier N, Leclercq B, Drobecq H, Vicogne J, Agouridas V, Melnyk O. Nat Commun. 2020 May 22;11(1):2558. 🡭
• Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production. Sencio V, Barthelemy A, Tavares LP, Machado MG, Soulard D, Cuinat C, Queiroz-Junior CM, Noordine ML, Salomé-Desnoulez S, Deryuter L, Foligné B, Wahl C, Frisch B, Vieira AT, Paget C, Milligan G, Ulven T, Wolowczuk I, Faveeuw C, Le Goffic R, Thomas M, Ferreira S, Teixeira MM, Trottein F. Cell Rep. 2020 Mar 3;30(9):2934-2947.e6. 🡭
• Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. Ayari A, Rosa-Calatrava M, Lancel S, Barthelemy J, Pizzorno A, Mayeuf-Louchart A, Baron M, Hot D, Deruyter L, Soulard D, Julien T, Faveeuw C, Molendi-Coste O, Dombrowicz D, Sedano L, Sencio V, Le Goffic R, Trottein F, Wolowczuk I. Commun Biol. 2020 May 14;3(1):237
• Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis. Machelart A, Salzano G, Li X, Demars A, Debrie AS, Menendez-Miranda M, Pancani E, Jouny S, Hoffmann E, Deboosere N, Belhaouane I, Rouanet C, Simar S, Talahari S, Giannini V, Villemagne B, Flipo M, Brosch R, Nesslany F, Deprez B, Muraille E, Locht C, Baulard AR, Willand N, Majlessi L, Gref R, Brodin P. ACS Nano. 2019 Apr 23;13(4):3992-4007. 🡭

Collaborations/Partners/Scientific clients

National:
INRA Rennes, IBCP Lyon, Université de Toulouse, Université de Guyane, Sorbonne, Université Paris-Sud

International:
University of Western Ontario (Canada), University of Ghent (Belgium), Jacobs University (Germany), University of Helsinki (Finland)

Collaborations/Partners/Private Clients

BIOVERSYS

Services offers

Applications sectors

  • Health / wellness
  • Education / Training
  • Science / Research

Services provided

• Identification and development of antimicrobial peptides
• Development of new powerful analgesics
• Identification of new antiviral targets
• Development of new diagnostic tools
• Identification of naturally occurring antivirals
• Design of appropriate delivery systems and formulations for aerosol therapy in humans
• Studies of the impact of antibiotic treatment on the modulation of host immunity in pulmonary infections ...

Consulting services

We provide consulting services related to all our areas of expertise.

Equipments

We possess a wide range of equipment regrouped within the internal and external technological platforms:
• BioImaging Center
• Transcriptomics and Applied Genomics Platform
• Modified Peptide and Proteomics Platform
• Chemical Systems Biology Platform
• Bioinformatics Platform
• Sub-Saharan Clinical Research Platform
• Animal facility
• Insectarium

We also have the BSL2 and BSL3 laboratories as well as all the basic equipment (cell culture equipment, cell and molecular biology, etc.).

Ecosystem

Affiliated institutions / organisations

CHU de Lille
Inserm
University of Lille
CNRS
Institut Pasteur de Lille

Equipex/EquipEx+/ESR

Doctoral schools

Regional strategic areas of activity

  • Health and Nutrition
    • New therapeutic approaches

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Thematics

Current thematics

  • Health and Nutrition
    • New therapeutic approaches
Title

Current content

Center for Infection & Immunity of Lille
Type

Current content

Research unit
Description

Current content

The Center for Infection & Immunity of Lille (CIIL) develops research projects on the molecular and cellular mechanisms of infectious and chronic inflammatory diseases with the aim to apply this knowledge to the development of improved diagnostics, vaccines and therapeutics. To achieve these goals, our Center gathers complementary expertise, covering a wide range of disciplines from epidemiology, molecular and cellular virology, bacteriology and parasitology, to the immunological basis of infectious and non-infectious diseases and translation into clinical applications. The CIIL studies bacterial, viral and parasitic diseases and the immune reaction against these infections as well as related immune dysfunctions of non-infectious diseases such as allergic asthma and chronic obstructive pulmonary disease (COPD). We also work on opportunistic infections in the context of cystic fibrosis which is the most frequent human genetic disease. The major infectious diseases that we investigate are tuberculosis, pneumococcal pneumonia, whooping cough, plague, hepatitis C and E, influenza, Middle East respiratory syndrome (MERS), COVID-19, malaria, schistosomiasis, toxoplasmosis, cryptosporidiosis and blastocystosis.
Contact informations
Contact

Current content

Contact name Email phone number
DUBUISSON Jean direction_ciil@ibl.fr (+33) 3 20 87 11 60
URL

Current content

https://www.ciil.fr/

Address

Current content

1 Rue du Professeur Calmette
Campus de l’Institut Pasteur de Lille, Université de Lille
59000 LILLE
Keywords

Current content

Infection, Immunity, Anti-infectives, Respiratory disorders, Infectious diseases, Antibiotics, Virology, Bacteria
Our search domains
Skills

Current content

• Epidemiology • Molecular and cellular virology • Bacteriology and parasitology • Immunological basis of infectious and non-infectious diseases • Chemical Genomics of Intracellular Mycobacteria • Opportunist Infection, Immunity, Environment & Lung Diseases • Chemical Biology of Antibiotics • Biology of Apicomplexan Parasites • Cellular Microbiology And Physics Of Infection • Chemical Biology of Flatworms • Research on Mycobacteria and Bordetella • Tropical Biome & Immuno-Pathophysiology • Plague & Yersinia pestis • Bacteria, Antibiotics and Immunity • Influenza, Immunity and Metabolism • Pulmonary Immunity • Ecology & Physiopathology of Intestinal Protozoa
Workforce

Current content

Nombre de chercheurs : 125
Nombre de doctorants :
Nombre de personnel d'appui à la recherche : 31
Effectif total : 221
Example(s) of projects

Current content

• ERC: ANTIBIOCLICKS • European programs: ERA4TB, FAIR, PHYS2BIOMED • Investments for the Future programme: LABEX PARAFRAP, IHU RESPIRE • CPER RESISToMICS
Example(s) of publications

Current content

• TgAP2IX-5 is a key transcriptional regulator of the asexual cell cycle division in Toxoplasma gondii. Khelifa AS, Guillen Sanchez C, Lesage KM, Huot L, Mouveaux T, Pericard P, Barois N, Touzet H, Marot G, Roger E, Gissot M. Nat Commun. 2021 Jan 7;12(1):116. 🡭 • A cysteine selenosulfide redox switch for protein chemical synthesis. Diemer V, Ollivier N, Leclercq B, Drobecq H, Vicogne J, Agouridas V, Melnyk O. Nat Commun. 2020 May 22;11(1):2558. 🡭 • Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production. Sencio V, Barthelemy A, Tavares LP, Machado MG, Soulard D, Cuinat C, Queiroz-Junior CM, Noordine ML, Salomé-Desnoulez S, Deryuter L, Foligné B, Wahl C, Frisch B, Vieira AT, Paget C, Milligan G, Ulven T, Wolowczuk I, Faveeuw C, Le Goffic R, Thomas M, Ferreira S, Teixeira MM, Trottein F. Cell Rep. 2020 Mar 3;30(9):2934-2947.e6. 🡭 • Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. Ayari A, Rosa-Calatrava M, Lancel S, Barthelemy J, Pizzorno A, Mayeuf-Louchart A, Baron M, Hot D, Deruyter L, Soulard D, Julien T, Faveeuw C, Molendi-Coste O, Dombrowicz D, Sedano L, Sencio V, Le Goffic R, Trottein F, Wolowczuk I. Commun Biol. 2020 May 14;3(1):237 • Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis. Machelart A, Salzano G, Li X, Demars A, Debrie AS, Menendez-Miranda M, Pancani E, Jouny S, Hoffmann E, Deboosere N, Belhaouane I, Rouanet C, Simar S, Talahari S, Giannini V, Villemagne B, Flipo M, Brosch R, Nesslany F, Deprez B, Muraille E, Locht C, Baulard AR, Willand N, Majlessi L, Gref R, Brodin P. ACS Nano. 2019 Apr 23;13(4):3992-4007. 🡭
Collaborations/Partners/Scientific clients

Current content

National: INRA Rennes, IBCP Lyon, Université de Toulouse, Université de Guyane, Sorbonne, Université Paris-Sud International: University of Western Ontario (Canada), University of Ghent (Belgium), Jacobs University (Germany), University of Helsinki (Finland)
Collaborations/Partners/Private Clients

Current content

BIOVERSYS
Services offers
Training offers

Current content

Services offers

Current content

• Identification and development of antimicrobial peptides • Development of new powerful analgesics • Identification of new antiviral targets • Development of new diagnostic tools • Identification of naturally occurring antivirals • Design of appropriate delivery systems and formulations for aerosol therapy in humans • Studies of the impact of antibiotic treatment on the modulation of host immunity in pulmonary infections ...
Consulting services

Current content

We provide consulting services related to all our areas of expertise.
Equipments
Equipements spécifiques

Current content

  • Atomic Force Microscopy Plateau
  • Bruker Catalyst microscope coupled to a videomicroscope TIRF 2 lasers Zeiss (LNSB2)
    Catalyst/ BRUKER
  • Atomic force microscope coupled to a PALM Elyra Zeiss
    Resolve/ Bruker
  • CIIL - Atomic force microscope
    FastScan Bio/ Brucker
  • Atomic force microscope
    Multimode 8/ BRUKER
  • Atomic force microscope coupled to STED/RESOLFT Abberior Instr. (super-resolution)
    Nanowizard 3 Ultra / JPK
  • JPK BioMat coupled to a Zeiss inverted microscope
    Biomat/ JPK
Ecosystem
Affiliated institutions / organisations

Current content

  • CHU de Lille
  • Inserm
  • University of Lille
  • CNRS
  • Institut Pasteur de Lille
Établissement(s) partenaire(s)

Current content

Unit(s) of attachment

Current content

Groups/Networks/Federations

Current content

Doctoral schools

Current content

Equipex/EquipEx+/ESR

Current content

Competitive cluster

Current content

Regional strategic areas of activity

Current content

  • Health and Nutrition
  • New therapeutic approaches
Personal informations
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