Institute for Translational Research in Inflammation (INFINITE)

Contact name	Email	phone number
CHAMEROY Virginie	virginie.chameroy@inserm.fr	(+33) 3 20 62 35 84
DUBUQUOY Laurent	contact.lille-inflammation@inserm.fr	(+33) 3 20 97 42 08

http://lille-inflammation-research.org/fr/

1, Place de Verdun
Pôle Recherche de la Faculté de Médecine, Campus Santé, Université de Lille
59045 LILLE

• Clinical and food bacteriology • Big data and deep learning • Functional characterization of the inflammatory status of microbial strains • Chemistry and Drug Design • Surgery • Effects of air and food pollutants on inflammation and gut dysbiosis • Environment • Epidemiology • Evaluation of antimicrobial molecules • Risk assessment • Fibrosis • Immunology • Immunotoxicology • Inflammation • Chronic inflammatory diseases • Microbiology • Intestinal microbiota • Microbes and intestinal homeostasis • Molecular modeling • Nutrition • Clinical observation and follow-up • Pathophysiology of epithelia • Digestive pathophysiology • Anti-inflammatory therapies

Nombre de chercheurs : 64
Nombre de doctorants :
Nombre de personnel d'appui à la recherche : 37
Effectif total : 128

• CPER Climibio/ECRIN • CPER RESIST-OMICs: Resistance and Complication in Chronic Inflammatory Diseases • FHU PRECISE (Precision Health in Complex Immune-Mediated Inflammatory Disease) • Label Team FRM • ANR EVICTION • I-Site ULNE pilot project "Santé Environnement" • I-Site ULNE pilot project "Phenomix" • Projet HdF STIMULE "IMPULSE" • Projet HdF STARTAIRR "PARTICIPE: Potential of TGR5 Receptor Agonists in Colon and Intestine Inflammation: Experimental Evidence" • Mechanism of regulation of lactase gene expression • Failure of liver regeneration in the context of alcoholic hepatitis

• Dubuquoy L, Louvet A, Lassailly G, Truant S, Boleslawski E, Artru F, Maggiotto F, Gantier E, Buob D, Leteurtre E, Cannesson A, Dharancy S, Moreno C, Pruvot FR, Bataller R, Mathurin P. (2015). Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis, Gut. 64(), 1949-60, DOI: 10.1136/gutjnl-2014-308410 🡭 • Bernocchi B, Carpentier R, Lantier I, Ducournau C, Dimier-Poisson I, Betbeder D (2016). Mechanisms allowing protein delivery in nasal mucosa using NPL nanoparticles., J Control Release. 232(), 42-50, DOI: 10.1016/j.jconrel.2016.04.014 🡭 • Vignal C, Pichavant M, Alleman LY, Djouina M, Dingreville F, Perdrix E, Waxin C, Ouali Alami A, Gower-Rousseau C, Desreumaux P, Body-Malapel M. (2017). Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon, Part Fibre Toxicol. 14(1), 46, DOI: 10.1186/s12989-017-0227-z 🡭 • Tuo W, Leleu-Chavain N, Spencer J, Sansook S, Millet R, Chavatte P (2017). Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors, J Med Chem. 60(1), 4-46, DOI: 10.1021/acs.jmedchem.6b00538 🡭 • Sanges S, Jendoubi M, Kavian N, Hauspie C, Speca S, Crave JC, Guerrier T, Lefèvre G, Sobanski V, Savina A, Hachulla E, Hatron PY, Labalette M, Batteux F, Dubucquoi S, Launay D (2017). . B Cell Homeostasis and Functional Properties Are Altered in an Hypochlorous Acid-Induced Murine Model of Systemic Sclerosis, Front Immunol. 8(), 53, DOI: 10.3389/fimmu.2017.00053 🡭

National: Institut Cochin, Paris, Institut Mondor de recherche biomedicale, Créteil, LPCA, ULCO, ULCO, ANSES, UMR 454 MEDIS, UMR 1241, Inserm, Université de Rennes 1, UMR1137, Paris, UMR1071, Université de Clermont Auvergne International: University of Perugia (Italy), University of Oslo (Norway), University of Zurich (Switzerland), Leeds (UK), Royal Free Hospital London (UK)

CSL Behring, OctaPharma, Takeda, Boehringer-Ingelheim, Siemens Healthineers Société Lesaffre

• Master Degree on Drug Design
• Support for health care professionals

• Histological analysis • Multiplex microfluidic analysis • Molecular modeling • Tomography • Confocal and fluorescence imaging • Identification of predictive biomarkers for the onset and progression of inflammatory diseases • Identification of the causes of pathological inflammatory phenomena • Development of new experimental animal models • Models of experimental fibrosis • Analysis of the immune response • Preclinical evaluation of anti-inflammatory and/or antifibrotic treatments • Chemo-induced colitis models: DSS, TNBS, oxazolone • Enteritis models: indomethacin, piroxicam • Spontaneous enterocolitis model: IL10 KO mice • Colorectal Cancer Model (AOM-DSS) • Intestinal fibrosis model • Oral, intraperitoneal, intravenous, intrarectal, intranasal, inhalation or via alzet pumps • Adult, gestational, perinatal exposure • Acute, sub-chronic and chronic exposures Parameters evaluated : Endoscopic scores of colitis and tumorigenesis | Histological scores of colitis, enteritis, fibrosis and dysplasia | Quantification of the inflammatory response: Cytokines/chemokines/immune populations. qRT-PCR, Elisa, Western Blot, Immunohistochemistry, Flow cytometry | Epigenetic markers | Intestinal permeability (in vivo functional tests, in vitro TEER) | Measurement of oxidative stress | Dysbiosis (metagenomic analysis by 16S sequencing) | Cytotoxicity tests, viability, cell proliferation, cell cycle, apoptosis • Performing antibiograms • Evaluation of antimicrobial molecules on a panel of reference bacterial strains (aerobic and anaerobic) • Determination of minimum inhibitory concentrations (MIC) of potentially bactericidal or bacteriostatic molecules, in solid and liquid media • Evaluation of the anti-inflammatory potential of bacterial strains (cytokine induction test on human circulating blood mononuclear cells = PBMC) • In vivo evaluation of the anti-inflammatory potential of bacterial strains in mouse models of experimental colitis (TNBS & DSS)

We provide consulting services related to all our areas of expertise.

• CHU de Lille
• Inserm
• University of Lille

SFR SF2i FAI²R - Health chain of rare autoimmune and autoinflammatory diseases

• Health and Nutrition
• Safe, healthy and sustainable food
• Chemistry and Materials
• Green chemistry
• Genetics, biomarkers and biomolecules
• Food ingredients
• New therapeutic approaches
• Digital World and Robotics
• Artificial intelligence, image processing, data science
• Medicine of the future: new health equipment and e-health
• Organic chemistry