Since 2003, the LPCM has brought together lecturer-researchers and clinicians to study ionic homeostasis and its signalling in cancer.
The ambition of our laboratory is to develop translational research with clinicians on the role of ion channels in cancer.
The members of our laboratory have developed and created new university courses around this theme.
This dynamic allows the LPMC to attract the best students, who can both benefit from quality training and have their national and/or international mobility encouraged.
Our scientific work also consolidates research in oncogenesis in the region, and allows it to be anchored in the Cancéropôle Nord-Ouest.
In addition, the project can lead to an important contribution to understanding the role of these new markers and/or therapeutic targets, ionic channels, in cancer biology.
Tumorothèque de Picardie and the Anatomie et Cytologie Pathologiques department) studies the role of ion channels in the cancer pathophysiology of the human mammary gland, as well as ion homeostasis in lung and pancreatic cancers.
The research unit thus contributes to the understanding of the role ́
of new markers and/or new therapeutic targets that are ion
channels in cancer biology.
The research carried out within the LPCM is structured around three axes:
• The impact of the hypoxic and acidic tumour environment and of extracellular matrix elements on cell survival and cell migration and invasion: involvement of the
Kv10.1/Orai1 couple, the TRPM7 channel and other ion transporters
• The Orai3/Stim1/IP3R complex in chemotherapy resistance and metastasis
• The TRPM7 «chanzyme» in the regulation of matrix
metalloproteinase secretion, magnesium homeostasis, and in the activation of pancreatic stromal cells and their interaction with pancreatic cancer cells
These three questions are complemented by translational
studies evaluating the role of ion channels as diagnostic, prognostic and/or therapeutic markers in human histopathology.
Example(s) of projects
Role of ion carriers in pancreatic cancer under the influence of an acid tumour microenvironment
Total budget: €4M - LPCM budget: €274,802
2. Capdaste project (INSERM) - 2021-2022
Total budget: €21,200
Partner 1: CANTHER, Inserm UMR-S1277 CNRS UMR9020
Partner 2: University of Reims, Faculty of Medicine, UMR CNRS 7369 MEDyC
3. Project "Role of the Orai3/STIM1/IP3R (OSIR) Reticulo-Membranar Complex in the Formation of Mammary Metastases". (Cancéropôle Nord-Ouest – 2022-2023)
Total budget: €20,000
4. Projet TRCP1 - The interplay between the calcium channel TRPC1 and the acidic tumour microenvironment in pancreatic ductal adenocarcinoma (Ligue Contre le Cancer 2022-2023)
Budget total : 25 000 €
Porteur : LPCM
5. PARAVETOX project [Enhancement of parasitoid hymenoptera venom toxins] (Hauts-de France region, START AIRR, 2019-2020)
Characterization of the anti-cancer toxins of Azobara japonica venom.
Budget: 75 k€ + 1 post-doctoral (1 year).
Owner: EDYSAN (UPJV);
Example(s) of publications
2. Ouadid-Ahidouch H, Morjani H, Schnipper J, Girault A, Ahidouch A. Rev Physiol Biochem Pharmacol. Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression. 2020 Aug 7. 🡭
3. Foulon A., Theret P, Rodat-Despoix L, Kischel P. Beyond chemotherapies : Recent strategies in breast cancer treatment. Cancers (Basel). 2020 Sep 16;12(9):2634. 🡭
4. Rodat-Despoix L, Chamlali M, Ouadid-Ahidouch H. - Ion channels as key partners of cytoskeleton in cancer disease. Biochim Biophys Acta Rev Cancer. 2021 Sep 11:188627. 🡭
5. Lefebvre T, Rybarczyk P, Bretaudeau C, Vanlaeys A, Cousin R, Brassart-Pasco S, Chatelain D, Dhennin-Duthille I, Ouadid-Ahidouch H, Brassart B, Gautier M.
TRPM7/RPSA Complex Regulates Pancreatic Cancer Cell Migration. Front Cell Dev Biol. 2020 Jul 8;8:549. 🡭
All publications can be found here : 🡭
International : Max-Planck-Institute of Experimental Medicine (Göttingen, Germany), Institute of Physiology II (Munster, Allemagne
▫ Microbiological safety stations (MSP)II
▫ Thermostatically controlled CO2 and hypoxia incubators
▫ Automatic cell counter
▫ Cell electroporation system
▫ Zeiss and Olympus microscopes...
▫ Electrophoresis system
▫ Shaking and dry incubation system
▫ Micro-grinding system
• Cell physiology
▫ Patch-Clamp facilities
▫ Cation imaging facilities
▫ Hypoxia chamber
• Human specimens
▫ Histopathology (ACP Department of Amiens-Picardie University Hospital)
▫ Collection of tissue samples
▫ Paraffin embedding
▫ Microtome sectioning
▫ In situ hybridization (Benchmark Ultra, Ventana instruments)...
• Picardie Tumour Library (ISO 9001-2015 certified)
▫ Cryopreservation in Nitrogen Vapour and Liquid Nitrogen : -140°C or -196°C
▫ Preservation -80°C, 4°C, Ambient T° (cryo monitoring and alarms)...
The laboratory also has equipment for molecular biology, bacteriology and immunodetection.
Affiliated institutions / organisations
Regional strategic areas of activity
- Chemistry and Materials
- Organic chemistry
- Health and Nutrition
- Food ingredients
- Medicine of the future: new health equipment and e-health
- New therapeutic approaches
- Prevention, well-being and the silver economy