• Health and Nutrition

Laboratory of Virology

Research unit - ULR 3610


Our laboratory studies the mechanisms involved in the pathogenesis of enteroviral infections and in the development of type 1 diabetes. We are also looking for ways to control these infections. Enterovirus infections are studied through the coxsackievirus B4 (CVB4) serotype used as a model.


  • Didier Hober


Centre Paul Boulanger, Boulevard du Professeur Jules Leclerc,
Hôpital Albert Calmettte, CHRU Lille
59037 LILLE


Effectif total : 15

Personnel de recherche : 5

Personnel d'appui à la recherche : 4



• Conventional, molecular and serological virology
• Enterovirus and in particular coxsackievirus B4
• Viral parthogenesis of type 1 diabetes
• In vitro and in vivo models (animals)
• Detection and identification of enteroviruses
• Culture in anaerobic environment (fermentations), gnotobiology
• Pathogenesis of viral infection
• Infection control and prevention. Viral inactivation (virucidal tests)
• Viral infection markers

Collaborations/Partners/Scientific clients

Arts et Métiers ParisTech, INRIA

Université d'Exeter (UK), Université de Tampere (Finland), Université de Liège (Belgium), Université Monastir (Tunisia), LIMMS (Japan), CHU Brazzaville (Congo)

Services offers

Applications sectors

  • Science / Research

Services provided

• Detection and quantification of enteroviruses in biological media (isolation in cell culture)
• Detection of enterovirus RNA in biological media (RT-PCR, semi-nested RT-PCR) and quantification of enterovirus RNA (quantitative real-time RT-PCR).
• Detection of anti-enterovirus antibodies in biological media
• Development of anti-enterovirus antibody detection tests
• Detection of human and murine type 1 IFN by biological method.
• Antiviral activity tests of molecules and products against enteroviruses
• Virucidal activity tests of molecules and products against different families of viruses
• Analysis of the intestinal flora (cultivable and non-cultivable bacteria)
• Bacterial translocation in animals with controlled or conventional flora (NOD, DBA1, C3H)

Consulting services

We provide consulting services related to all our areas of expertise.


We possess a wide range of equipment, including:
• BSL2 and BSL2 + with PSM2 and CO2 incubators: cell and virus culture
• Thermal cyclers and real-time PCR machine
• Plate reader and washer (ELISA)
• Delayed fluorescence reader (DELFIA)
• UV microscope (fluorescence and immunofluorescence)
• Electrophoresis, chromatography (gel filtration, affinity)
• Ultracentrifuge
• Anaerobic chamber, isolators, fermenters


Affiliated institutions / organisations

Doctoral schools

Regional strategic areas of activity

  • Health and Nutrition
    • New therapeutic approaches
    • Prevention, well-being and the silver economy