• Health and Nutrition

Lille Neurosciences & Cognition (LilNCog JPArc)

Research unit - UMR-S 1172


Our laboratory is devoted to neurological diseases, mental health and neuroendocrinology. Our research focuses on the blood-brain barrier, stroke, neuroevolutionary diseases and mental health. We are working to improve diagnostic and therapeutic approaches for brain diseases. We address all areas of research from molecular to systemic.


  • Luc Buee


1 place de Verdun, Bâtiment Biserte
Campus Santé, Université de Lille
59045 LILLE


Lille Neurosciences & Cognition


Effectif total : 243

Personnel de recherche : 122

Personnel d'appui à la recherche : 57



• Postnatal brain development
• Central control of food intake
• Central control of reproduction
• Neurological diseases and disabilities
• Alzheimer's disease and related disorders
• Parkinson's disease and parkinsonian syndromes
• Autoimmune encephalopathies
• Mental health and psychiatry
• Neuroendocrinology
• Blood-brain barrier
• Stroke
• Diagnostic and therapeutic approaches for brain diseases
• Pre-clinical and clinical modeling of degenerative and vascular cognitive disorders

Example(s) of projects

• Tanycytes: an opening to the brain 🡭
• Psychotrauma 🡭
• ARIANES: brain MRI regional network 🡭🡭

Example(s) of publications

• Barus R, Béné J, Deguil J, Gautier S, Bordet R. Drug interactions with dementia-related pathophysiological pathways worsen or prevent dementia. Br J Pharmacol. 2019 Sep;176(18):3413-3434. doi: 10.1111/bph.14607. Epub 2019 Mar 31. PMID: 30714122; PMCID: PMC6715604 🡭
• Colin M, Dujardin S, Schraen-Maschke S, Meno-Tetang G, Duyckaerts C, Courade JP, Buée L. From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy. Acta Neuropathol. 2020 Jan;139(1):3-25. doi: 10.1007/s00401-019-02087 🡭
• Prevot V, Dehouck B, Sharif A, Ciofi P, Giacobini P, Clasadonte J. The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism. Endocr Rev. 2018 Jun 1;39(3):333-368. doi: 10.1210/er.2017-00235. PMID: 29351662 🡭
• Leroy A, Amad A, D'Hondt F, Pins D, Jaafari N, Thomas P, Jardri R. Reward anticipation in schizophrenia: A coordinate-based meta-analysis. Schizophr Res. 2020 Apr;218:2-6. doi: 10.1016/j.schres.2019.12.041. Epub 2020 Jan 14. PMID: 31948895 🡭
• Goveas L, Mutez E, Chartier-Harlin MC, Taymans JM. Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells. Cells. 2021 Apr 22;10(5):981. doi: 10.3390/cells10050981. PMID: 33922322; PMCID: PMC8145309 🡭

Collaborations/Partners/Scientific clients

Jules Bordet Institute, Inria

Academia Sinica (Taiwan), Saban Research Institute (USA), University of Sheffield (UK), University of Munich (Germany), University of Rostock (Germany), University of Leeds (UK), Taiwan Medical University (Taiwan)

Collaborations/Partners/Private Clients

Theranexus, Firalis, MetaBrain, Siemens, HCS Pharma, UCB Pharma, AlzProtecT

Services offers

Applications sectors

  • Biotechnology
  • Health / wellness
  • Science / Research

Services provided

We are unable to offer any services at this time.

Consulting services

We provide consulting services related to all our areas of expertise.

Offres technologiques

  • LSR: New molecules for neurodegenerative diseases treatment
    A new family of molecules with a new structure demonstrated in vitro efficacy, selectivity and low cytotoxicity. In vivo results confirm the therapeutical potential of this new family. Read more


We possess a wide range of equipment for:
• sample preparation (preparation, ultracentrifugation, sonication, fragmentation, tissue sectioning, processing...)
• study of proteins (characterization, molecular interactions)
• study of nucleic acids (amplification, dosage)
• Imaging (microscope, scanner, camera, electrophysiology, functional exploration...)

See the detailed list of equipment: https://lilncog.eu/plateaux-techniques-de-lille-neuroscience-et-cognition/.


Affiliated institutions / organisations



Doctoral schools

Regional strategic areas of activity

  • Health and Nutrition
    • New therapeutic approaches