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Health and Nutrition
Lille Neurosciences & Cognition (LilNCog JPArc)
Research unit - UMR-S 1172
Our laboratory is devoted to neurological diseases, mental health and neuroendocrinology. Our research focuses on the blood-brain barrier, stroke, neuroevolutionary diseases and mental health. We are working to improve diagnostic and therapeutic approaches for brain diseases. We address all areas of research from molecular to systemic.
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Luc Buee
Director
1 place de Verdun, Bâtiment Biserte
Campus Santé, Université de Lille
59045 LILLE
Effectif
Effectif total : 243
Personnel de recherche : 122
Personnel d'appui à la recherche : 57
Skills
• Central control of food intake
• Central control of reproduction
• Neurological diseases and disabilities
• Alzheimer's disease and related disorders
• Parkinson's disease and parkinsonian syndromes
• Autoimmune encephalopathies
• Mental health and psychiatry
• Neuroendocrinology
• Blood-brain barrier
• Stroke
• Diagnostic and therapeutic approaches for brain diseases
• Pre-clinical and clinical modeling of degenerative and vascular cognitive disorders
Example(s) of projects
Example(s) of publications
• Colin M, Dujardin S, Schraen-Maschke S, Meno-Tetang G, Duyckaerts C, Courade JP, Buée L. From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy. Acta Neuropathol. 2020 Jan;139(1):3-25. doi: 10.1007/s00401-019-02087 🡭
• Prevot V, Dehouck B, Sharif A, Ciofi P, Giacobini P, Clasadonte J. The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism. Endocr Rev. 2018 Jun 1;39(3):333-368. doi: 10.1210/er.2017-00235. PMID: 29351662 🡭
• Leroy A, Amad A, D'Hondt F, Pins D, Jaafari N, Thomas P, Jardri R. Reward anticipation in schizophrenia: A coordinate-based meta-analysis. Schizophr Res. 2020 Apr;218:2-6. doi: 10.1016/j.schres.2019.12.041. Epub 2020 Jan 14. PMID: 31948895 🡭
• Goveas L, Mutez E, Chartier-Harlin MC, Taymans JM. Mind the Gap: LRRK2 Phenotypes in the Clinic vs. in Patient Cells. Cells. 2021 Apr 22;10(5):981. doi: 10.3390/cells10050981. PMID: 33922322; PMCID: PMC8145309 🡭
Collaborations/Partners/Scientific clients
Jules Bordet Institute, Inria
International:
Academia Sinica (Taiwan), Saban Research Institute (USA), University of Sheffield (UK), University of Munich (Germany), University of Rostock (Germany), University of Leeds (UK), Taiwan Medical University (Taiwan)
Collaborations/Partners/Private Clients
Applications sectors
- Biotechnology
- Health / wellness
- Science / Research
Services provided
Consulting services
Offres technologiques
- LSR: New molecules for neurodegenerative diseases treatment
A new family of molecules with a new structure demonstrated in vitro efficacy, selectivity and low cytotoxicity. In vivo results confirm the therapeutical potential of this new family. Read more
• sample preparation (preparation, ultracentrifugation, sonication, fragmentation, tissue sectioning, processing...)
• study of proteins (characterization, molecular interactions)
• study of nucleic acids (amplification, dosage)
• Imaging (microscope, scanner, camera, electrophysiology, functional exploration...)
See the detailed list of equipment: https://lilncog.eu/plateaux-techniques-de-lille-neuroscience-et-cognition/.
Affiliated institutions / organisations
Groups/Networks/Federations
Equipex/EquipEx+/ESR
Doctoral schools
Regional strategic areas of activity
- Health and Nutrition
- New therapeutic approaches