• Chemistry and Materials
  • Health and Nutrition

Pathophysiological Mechanisms and Consequences of Cardiovascular Calcifications (MP3CV)

Research unit - UR 7517


Cardiovascular diseases are responsible for significant mortality.
Their cause is multifactorial: aging, lifestyle, diseases (diabetes, chronic kidney failure).
Among the aggravating factors, the presence of calcifications in the vessels and heart valves greatly increases the cardiovascular risk. The mechanisms behind these calcifications are not yet fully known and, to date, there are no effective therapies to stop or slow their development.

This Unit works to improve pathophysiology knowledge and therapeutic management of these calcifications.


  • Saïd KAMEL
  • Chantal ALLOU


Avenue René Laënnec
80054 AMIENS



Effectif total : 50

Personnel de recherche : 38

Personnel d'appui à la recherche : 6



The Unit’s research project is to identify:

1. Molecular mechanisms involved in calcification processes and associated factors/markers.
2. Hemodynamic and structural consequences of cardiovascular calcifications in animals and humans.
3. Therapeutic strategies to prevent and treat these calcifications.

This Unit uses conventional biochemistry and molecular biology techniques of research:

• Cell culture
• Western Blot
• Infrared, Immunohistochemistry
• Flow cytometry
• Animal testing

Example(s) of projects

1. ANR project "The role of vasorine in the dialogue between bone, kidney and vessels":

Exploration of the role of vasorine in vascular disorders and calcification.
MP3CV Holder: Isabelle Six
Budget: €537 K (MP3CV: €70 K); Partners: Université Paris Descartes (carrier), UPJV (MP3CV), Max Planck Institute for Molecular Genetics, PARCC Paris Centre de Research Cardiovascular.

2. CALARTOS Project “Bone Arterial Calcification: Interest in Surgical Management of Long Bone Loss Using Masks”:

Exploration of reconstructive neo-synthesis, and in particular the molecular mechanisms of the action of the membrane induced during osteosynthesis; substitution of this arterial tissue-induced membrane to generate a new bone reconstruction medical practice.
MP3CV Wearer: Romuald Mentaverri
Budget: €200K
Partners: UPJV (carrier)

3. Project H2020 CaSR “Calcium-Sensing Receptor Therapeutics for Non Communicable Diseases”:

Increase knowledge of the role of the calcium-sensitive receptor (CaSR) in the pathogenesis of serious non-transmissible diseases (Alzheimer’s disease, cardiovascular diseases, type 2 diabetes, cancers, sarcopenia), and train young researchers in scientific excellence in the field of cellular signalling.
MP3CV carrier : Romuald Mentaverri
MP3CV budget: €262k

Example(s) of publications

1. Cellular and molecular mechanisms associated with ischemic stroke severity in female mice with chronic kidney disease.Hénaut L, Grissi M, Brazier F, Assem M, Poirot-Leclercq S, Lenglet G, Boudot C, Avondo C, Boullier A, Choukroun G, Massy ZA, Kamel S, Chillon JM.Sci Rep. 2019 Apr 23;9(1):6432. 🡭

2. VALIDATION AND APPLICATION OF A HPLC-DAD METHOD FOR ROUTINE THERAPEUTIC DRUG MONITORING OF CEFTOBIPROLE.Lima B, Bodeau S, Quinton MC, Leven C, Lemaire-Hurtel AS, Bennis Y.Antimicrob Agents Chemother. 2019 Apr 22. 🡭

3.The pharmacokinetic challenge of voriconazole therapy for cerebral aspergillosis in patients treated with ibrutinib.Nyga R, Simon L, Chouaki T, Delette C, Bennis Y, Joseph C, Marolleau JP, Slama M, Zogheib E, Maizel J.Crit Care. 2019 Mar 12;23(1):88. 🡭

4. Characteristics and Prognosis of Patients With Moderate Aortic Stenosis and Preserved Left Ventricular Ejection Fraction. Delesalle G, Bohbot Y, Rusinaru D, Delpierre Q, Maréchaux S, Tribouilloy C.J Am Heart Assoc. 2019 Mar 19;8(6):e011036. 🡭

5. Dipeptidyl Peptidase-4 Inhibition Prevents Vascular Calcification by Potentiating the Insulin-Like Growth Factor-1 Signaling Pathway. Varennes O, Mary A, Bricca G, Kamel S, Bellien J.JACC Basic Transl Sci. 2019 Feb 25;4(1):113-115. 🡭

All publications can be found here : 🡭

Collaborations/Partners/Scientific clients

National : Université de Rouen Normandie, Université de Caen Normandie, Université Paris Descartes, Université Paris Cité

International : Max Planck Institute for Molecular Genetics (Germany)

Services offers

Services provided

We provide services according to our expertise.

Consulting services

We provide consulting services according to our expertise.


This Unit is equipped with several rooms dedicated to cell culture (laboratory type L1 and L2), experimentation and surgery on small animal (rodent), biochemistry room, molecular biology, photo laboratory, microscopy rooms, Chemistry laboratory and storage rooms.
You can find the complete list of equipment here : 🡭

Biological materials

Rodent experiments and surgery, cell culture (laboratory type L1 and L2)


Affiliated institutions / organisations

Partner institution(s)

Doctoral schools

Regional strategic areas of activity

  • Chemistry and Materials
    • Organic chemistry
  • Health and Nutrition
    • Food ingredients
    • Medicine of the future: new health equipment and e-health
    • New therapeutic approaches
    • Prevention, well-being and the silver economy