• Chemistry and Materials
  • Health and Nutrition

Pathophysiological Mechanisms and Consequences of Cardiovascular Calcifications (MP3CV)

Research unit - UR 7517

Description

Cardiovascular diseases are responsible for significant mortality.
Their cause is multifactorial: aging, lifestyle, diseases (diabetes, chronic kidney failure).
Among the aggravating factors, the presence of calcifications in the vessels and heart valves greatly increases the cardiovascular risk. The mechanisms behind these calcifications are not yet fully known and, to date, there are no effective therapies to stop or slow their development.

This Unit works to improve pathophysiology knowledge and therapeutic management of these calcifications.

Contacts

  • Saïd KAMEL
    Director
  • Chantal ALLOU
    Secretary

Informations

Avenue René Laënnec
80054 AMIENS

https://mp3cv.u-picardie.fr/accueil-mp3cv-422954.kjsp

Effectif

Effectif total : 50

Personnel de recherche : 38

Personnel d'appui à la recherche : 6

Expertises

Skills

The Unit’s research project is to identify:

1. Molecular mechanisms involved in calcification processes and associated factors/markers.
2. Hemodynamic and structural consequences of cardiovascular calcifications in animals and humans.
3. Therapeutic strategies to prevent and treat these calcifications.

This Unit uses conventional biochemistry and molecular biology techniques of research:

• Cell culture
• Western Blot
• Infrared, Immunohistochemistry
• Flow cytometry
• qRT-PCR
• Animal testing

Example(s) of projects

1. ANR project "The role of vasorine in the dialogue between bone, kidney and vessels":

Exploration of the role of vasorine in vascular disorders and calcification.
MP3CV Holder: Isabelle Six
Budget: €537 K (MP3CV: €70 K); Partners: Université Paris Descartes (carrier), UPJV (MP3CV), Max Planck Institute for Molecular Genetics, PARCC Paris Centre de Research Cardiovascular.

2. CALARTOS Project “Bone Arterial Calcification: Interest in Surgical Management of Long Bone Loss Using Masks”:

Exploration of reconstructive neo-synthesis, and in particular the molecular mechanisms of the action of the membrane induced during osteosynthesis; substitution of this arterial tissue-induced membrane to generate a new bone reconstruction medical practice.
MP3CV Wearer: Romuald Mentaverri
Budget: €200K
Partners: UPJV (carrier)

3. Project H2020 CaSR “Calcium-Sensing Receptor Therapeutics for Non Communicable Diseases”:

Increase knowledge of the role of the calcium-sensitive receptor (CaSR) in the pathogenesis of serious non-transmissible diseases (Alzheimer’s disease, cardiovascular diseases, type 2 diabetes, cancers, sarcopenia), and train young researchers in scientific excellence in the field of cellular signalling.
MP3CV carrier : Romuald Mentaverri
MP3CV budget: €262k

Example(s) of publications

1. Cellular and molecular mechanisms associated with ischemic stroke severity in female mice with chronic kidney disease.Hénaut L, Grissi M, Brazier F, Assem M, Poirot-Leclercq S, Lenglet G, Boudot C, Avondo C, Boullier A, Choukroun G, Massy ZA, Kamel S, Chillon JM.Sci Rep. 2019 Apr 23;9(1):6432. 🡭

2. VALIDATION AND APPLICATION OF A HPLC-DAD METHOD FOR ROUTINE THERAPEUTIC DRUG MONITORING OF CEFTOBIPROLE.Lima B, Bodeau S, Quinton MC, Leven C, Lemaire-Hurtel AS, Bennis Y.Antimicrob Agents Chemother. 2019 Apr 22. 🡭

3.The pharmacokinetic challenge of voriconazole therapy for cerebral aspergillosis in patients treated with ibrutinib.Nyga R, Simon L, Chouaki T, Delette C, Bennis Y, Joseph C, Marolleau JP, Slama M, Zogheib E, Maizel J.Crit Care. 2019 Mar 12;23(1):88. 🡭

4. Characteristics and Prognosis of Patients With Moderate Aortic Stenosis and Preserved Left Ventricular Ejection Fraction. Delesalle G, Bohbot Y, Rusinaru D, Delpierre Q, Maréchaux S, Tribouilloy C.J Am Heart Assoc. 2019 Mar 19;8(6):e011036. 🡭

5. Dipeptidyl Peptidase-4 Inhibition Prevents Vascular Calcification by Potentiating the Insulin-Like Growth Factor-1 Signaling Pathway. Varennes O, Mary A, Bricca G, Kamel S, Bellien J.JACC Basic Transl Sci. 2019 Feb 25;4(1):113-115. 🡭

All publications can be found here : 🡭

Collaborations/Partners/Scientific clients

National : Université de Rouen Normandie, Université de Caen Normandie, Université Paris Descartes, Université Paris Cité


International : Max Planck Institute for Molecular Genetics (Germany)

Services offers

Services provided

We provide services according to our expertise.

Consulting services

We provide consulting services according to our expertise.

Equipments

This Unit is equipped with several rooms dedicated to cell culture (laboratory type L1 and L2), experimentation and surgery on small animal (rodent), biochemistry room, molecular biology, photo laboratory, microscopy rooms, Chemistry laboratory and storage rooms.
You can find the complete list of equipment here : 🡭

Biological materials

Rodent experiments and surgery, cell culture (laboratory type L1 and L2)

Ecosystem

Affiliated institutions / organisations

Partner institution(s)

Doctoral schools

Regional strategic areas of activity

  • Chemistry and Materials
    • Organic chemistry
  • Health and Nutrition
    • Food ingredients
    • Medicine of the future: new health equipment and e-health
    • New therapeutic approaches
    • Prevention, well-being and the silver economy

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Thematics

Current thematics

  • Chemistry and Materials
    • Organic chemistry
  • Health and Nutrition
    • Food ingredients
    • Medicine of the future: new health equipment and e-health
    • New therapeutic approaches
    • Prevention, well-being and the silver economy
Title

Current content

Pathophysiological Mechanisms and Consequences of Cardiovascular Calcifications
Type

Current content

Research unit
Description

Current content

Cardiovascular diseases are responsible for significant mortality.
Their cause is multifactorial: aging, lifestyle, diseases (diabetes, chronic kidney failure).
Among the aggravating factors, the presence of calcifications in the vessels and heart valves greatly increases the cardiovascular risk. The mechanisms behind these calcifications are not yet fully known and, to date, there are no effective therapies to stop or slow their development.

This Unit works to improve pathophysiology knowledge and therapeutic management of these calcifications.
Contact informations
Contact

Current content

Contact name Email phone number
KAMEL Saïd said.kamel@u-picardie.fr
ALLOU Chantal chantal.allou@u-picardie.fr 03 22 82 54 25
URL

Current content

https://mp3cv.u-picardie.fr/accueil-mp3cv-422954.kjsp

Address

Current content

Avenue René Laënnec

80054 AMIENS
Keywords

Current content

Health, Cardiovascular calcifications (CVC), Pathophysiology of CVC, Hemodynamic consequences of CVC, Chronic Renal Failure, Calcified Aortic Narrowing, Therapeutic Strategies, SARS-CoV-2 / COVID-19, Cardiology, Biology
Our search domains
Skills

Current content

The Unit’s research project is to identify: 1. Molecular mechanisms involved in calcification processes and associated factors/markers. 2. Hemodynamic and structural consequences of cardiovascular calcifications in animals and humans. 3. Therapeutic strategies to prevent and treat these calcifications. This Unit uses conventional biochemistry and molecular biology techniques of research: • Cell culture • Western Blot • Infrared, Immunohistochemistry • Flow cytometry • qRT-PCR • Animal testing
Workforce

Current content

Nombre de chercheurs : 38
Nombre de doctorants :
Nombre de personnel d'appui à la recherche : 6
Effectif total : 50
Example(s) of projects

Current content

1. ANR project "The role of vasorine in the dialogue between bone, kidney and vessels": Exploration of the role of vasorine in vascular disorders and calcification. MP3CV Holder: Isabelle Six Budget: €537 K (MP3CV: €70 K); Partners: Université Paris Descartes (carrier), UPJV (MP3CV), Max Planck Institute for Molecular Genetics, PARCC Paris Centre de Research Cardiovascular. 2. CALARTOS Project “Bone Arterial Calcification: Interest in Surgical Management of Long Bone Loss Using Masks”: Exploration of reconstructive neo-synthesis, and in particular the molecular mechanisms of the action of the membrane induced during osteosynthesis; substitution of this arterial tissue-induced membrane to generate a new bone reconstruction medical practice. MP3CV Wearer: Romuald Mentaverri Budget: €200K Partners: UPJV (carrier) 3. Project H2020 CaSR “Calcium-Sensing Receptor Therapeutics for Non Communicable Diseases”: Increase knowledge of the role of the calcium-sensitive receptor (CaSR) in the pathogenesis of serious non-transmissible diseases (Alzheimer’s disease, cardiovascular diseases, type 2 diabetes, cancers, sarcopenia), and train young researchers in scientific excellence in the field of cellular signalling. MP3CV carrier : Romuald Mentaverri MP3CV budget: €262k
Example(s) of publications

Current content

1. Cellular and molecular mechanisms associated with ischemic stroke severity in female mice with chronic kidney disease.Hénaut L, Grissi M, Brazier F, Assem M, Poirot-Leclercq S, Lenglet G, Boudot C, Avondo C, Boullier A, Choukroun G, Massy ZA, Kamel S, Chillon JM.Sci Rep. 2019 Apr 23;9(1):6432. 🡭 2. VALIDATION AND APPLICATION OF A HPLC-DAD METHOD FOR ROUTINE THERAPEUTIC DRUG MONITORING OF CEFTOBIPROLE.Lima B, Bodeau S, Quinton MC, Leven C, Lemaire-Hurtel AS, Bennis Y.Antimicrob Agents Chemother. 2019 Apr 22. 🡭 3.The pharmacokinetic challenge of voriconazole therapy for cerebral aspergillosis in patients treated with ibrutinib.Nyga R, Simon L, Chouaki T, Delette C, Bennis Y, Joseph C, Marolleau JP, Slama M, Zogheib E, Maizel J.Crit Care. 2019 Mar 12;23(1):88. 🡭 4. Characteristics and Prognosis of Patients With Moderate Aortic Stenosis and Preserved Left Ventricular Ejection Fraction. Delesalle G, Bohbot Y, Rusinaru D, Delpierre Q, Maréchaux S, Tribouilloy C.J Am Heart Assoc. 2019 Mar 19;8(6):e011036. 🡭 5. Dipeptidyl Peptidase-4 Inhibition Prevents Vascular Calcification by Potentiating the Insulin-Like Growth Factor-1 Signaling Pathway. Varennes O, Mary A, Bricca G, Kamel S, Bellien J.JACC Basic Transl Sci. 2019 Feb 25;4(1):113-115. 🡭 All publications can be found here : 🡭
Collaborations/Partners/Scientific clients

Current content

National : Université de Rouen Normandie, Université de Caen Normandie, Université Paris Descartes, Université Paris Cité International : Max Planck Institute for Molecular Genetics (Germany)
Collaborations/Partners/Private Clients

Current content

Services offers
Training offers

Current content

Services offers

Current content

We provide services according to our expertise.
Consulting services

Current content

We provide consulting services according to our expertise.
Equipments
Equipements spécifiques

Current content

  • MP3CV - Optima MAX-XP Ultracentrifuge
    Optima MAX-XP / Beckman Coulter
  • MP3CV - Cryostat CM 1950
    CM 1950 / Leica
  • Bioanalyzer 2100
    2100/ Agilent
  • Paraffining platform EG 1150C
    EG 1150C / Leica
  • PSM Type II Maxisafe 2020
    Maxisafe 2020/ Thermo Scientific
  • CO2 Incubator
    Thermo electro corporation
  • MP3CV - IBIDI system (4 pumps, 1 temperature controller, 1 generator)
  • 2 5804R Centrifuges
    5804R / Eppendorf
Ecosystem
Affiliated institutions / organisations

Current content

  • University of Picardie Jules Verne (UPJV)
Établissement(s) partenaire(s)

Current content

Unit(s) of attachment

Current content

Groups/Networks/Federations

Current content

Doctoral schools

Current content

Equipex/EquipEx+/ESR

Current content

Competitive cluster

Current content

Regional strategic areas of activity

Current content

  • Health and Nutrition
  • Chemistry and Materials
  • Food ingredients
  • New therapeutic approaches
  • Prevention, well-being and the silver economy
  • Medicine of the future: new health equipment and e-health
  • Organic chemistry
Personal informations
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