• Health and Nutrition

Research Group on Injectable Forms and Associated Technologies (GRITA)

Research unit - ULR 7365


Our research activities focus on injectable drugs, medical infusion devices and biopharmaceutical and pharmacokinetic modeling. Our objectives are to design, develop and evaluate healthcare technologies related to drug preparation and delivery. In particular, we develop devices for the automation of the preparation of injectable drugs, innovative medical devices for infusion as well as tools integrating augmented reality aiming at improving safety in the preparation of drugs. We also evaluate the stability of drugs and container/content interactions. We are open to all academic and industrial collaborations and propose services in line with our expertise.


  • Marie Lecoeur
  • Pascal Odou


3, Rue du Professeur Laguesse
Faculté de Pharmacie, Campus Santé, Université de Lille
59006 LILLE


Research Group on Injectable Forms and Associated Technologies


Effectif total : 36

Personnel de recherche : 21

Personnel d'appui à la recherche : 4



• Assessment of chemical contamination risks
• Evaluation of container-content compatibility
• Characterization of the properties of injectable drugs
• Evaluation of the degradation of active ingredients
• Analysis of particles in the perfused solutions
• Analysis of phenomena at the interface between the infused liquid and the wall of the infusion devices
• Studies of contamination risks related to the drug preparation phase
• Development and evaluation of medical devices

Example(s) of projects

• Development of a new medical device for the preparation and administration of cytotoxics
• Development of a new concept of infusion ramp allowing the improvement of hemodynamics, while reducing the risk of incompatibilities during the simultaneous infusion of several active ingredients
• Development of mathematical models for the fluctuations of the flow rate of gravity infusions

Example(s) of publications

• Beauvais D, Karleskind O, Loridant S, Nyga R, Lamiaux M, Moreau AS & al , Potential role of tocilizumab in severe gastrointestinal barrier damage after CAR T-cell therapy., J Microbiol Immunol Infect, 2021
• La Z, Danel C, Grolaux G, Charton J, Furman C, Lipka E , Electrophoretic separation of multiple chiral center analyte with a three cyclodextrins mixture., Electrophoresis, 2021
• Gilliot S, Ducloy-Bouthors AS, Hennart B, Loingeville F, Jeanne M, Lebuffe G & al , Hypothesis for a partially non urinary elimination of tranexamic acid in haemorrhagic caesarean section: TRACES pilot pharmacokinetic study: Pharmacokinetics of tranexamic acid in obstetrics., Eur J Pharm Sci, 2020 , 105486
• Simon N, Guichard N, Odou P, Decaudin B, Bonnabry P, Fleury-Souverain S , Efficiency of four solutions in removing 23 conventional antineoplastic drugs from contaminated surfaces., PLoS ONE, 2020 , e0235131
• Préta LH, Henry H, Masse M, Barthélémy C, Carta N, Foulon C & al , Instability of Insulin Aspart Diluted in Dextrose., Diabetes Care, 2020

See the complete list of publications here.

Collaborations/Partners/Scientific clients

Multiple national and international collaborations:

LIOD, C-Biosenss, Casimir, UMR990, Oscar Lambret Center...

University Hospital of Geneva (Switzerland), VU University Medical Center (Netherlands)...

Collaborations/Partners/Private Clients

Aseptic Technologies, Becton Dickinson, Didactic, Doran International, Delpharm, Mayoli Spindler, Genfit, Macopharma, Pierre Fabre, Pharmacolog & Pharmed, Pierre Fabre, Renaudin, Roquette

Services offers

Applications sectors

  • Biotechnology
  • Health / wellness
  • Education / Training
  • Science / Research

Services provided

• Study of mass flow rates and incompatibility phenomena during perfusion
• Study of the characteristics of the infusion set-up
• Determination of active ingredients, metabolites and degradation products by chromatography, electrophoresis or mass spectrometry
• Evaluation of new vials used in the manufacture of ready-to-use injectable forms
• Evaluation of the physicochemical stability of active ingredients in solution
• Evaluation of the adsorption of active ingredients on the body of the vials
• Evaluation of containment measures during the preparation of injectable drugs
• Modeling of liquid flow during simple and complex infusion

Training offers

• DU Aseptic preparations
• DU Implantable medical devices
• Master Science of drugs and healthcare products
Course: Medical devices and biomaterials
Course: Therapeutic optimization: from manufacturing to the clinic
• On-line training:
- Galenic Pharmacy (http://unt-ori2.crihan.fr/unspf/2010_Lille_Barthelemy_Decaudin_Odou_TP_pharmacie/co/Web.html)
- Quality management and good practices (http://unt-ori2.crihan.fr/unspf/2010_Lille_Odou_Qualite/co/Gestion%20de%20la%20Qualite_web.html)
- Sterilization (http://unt-ori2.crihan.fr/unspf/2009_Lille_Odou_Sterilisation/co/Preparations%20parenterales_web.html)

Consulting services

• HPLC/UV assay
• LC/MS assay
• GC-FID assay
• Stability studies
• Literature review / Clinical evaluation
• Infusion studies
• Incompatibility studies
• Expertise on infusion setups


We possess a wide range of equipment:
- Equipment for synthesis (rotary evaporators, pumping groups, heated magnetic stirrers...)
- Equipment for purification, identification and dosage (liquid chromatography-mass spectrometry, High Performance Liquid Chromatography (HPLC), Spectrophotometers, polarimeter, osmometer, particle counter...)
- Equipment for perfusion studies (dynamometer, flow meter, precision scales, pumps and syringe pumps, syringe pumps, granulometer, particle counters and analyzers...)
- Equipment for biopharmaceutical and pharmacotechnical studies (disaggregation apparatus, absorption study apparatus, compression machine, materials to assist formulation...)
- Imaging equipment
- Animal house for small animals and rodents
- Cell culture room (PSM, incubator, microscope, centrifuge...).
- ISO 6 cleanroom.
- Computer tools for bibliographic research and analysis.


Affiliated institutions / organisations


Doctoral schools

Regional strategic areas of activity

  • Health and Nutrition
    • Medicine of the future: new health equipment and e-health
    • New therapeutic approaches