• Health and Nutrition
  • Societal and economic transition & Risk management

Risk factors and molecular determinants of aging-related diseases (RID-AGE)

Research unit - U 1167

Description

The main goal of our laboratory is to analyze, explore and understand the trends and determinants of major chronic diseases (cardiovascular and neurodegenerative) related to aging in order to propose new approaches for prevention and treatment, paving the way for personalized medicine and increased life expectancy without disability. Our laboratory is open to collaborations.

Contacts

  • Philippe Amouyel
    Director

Informations

1 rue du professeur Calmette
Institut Pasteur de Lille
59019 LILLE

https://pasteur-lille.fr/centre-de-recherche/unites-de-recherche/facteurs-de-risque-et-determinants-moleculaires-des-maladies-liees-au-vieillissement/

Effectif

Effectif total : 79

Expertises

Skills

• Public Health
• High-throughput genomics, bioinformatics, High Content Screening
• Molecular aspects of aging pathologies
• Inflammaging
• Chronic diseases
• Cardiovascular, cerebrovascular and metabolic diseases
• Neurodegenerative diseases
• Alzheimer's disease
• Metabolism
• Glycation
• Study of membrane proteins and their post-translational modifications
• Analysis of molecular interactions

Collaborations/Partners/Scientific clients

National:
University of Paris, Sorbonne University, University of Bordeaux, INSB, University of Paris Saclay, CHU Bordeaux, Hopital Universitaire Pitie-Salpetriere - APHP, CHU Strasbourg, CHU de Toulouse, University of Strasbourg

International:
University of London (United Kingdom), Harvard University (United States), Helmholtz Association (Germany), Erasmus University Rotterdam (Netherlands), Karolinska Institutet (Sweden), University College London (United Kingdom), University of California System (United States), Ghent University (Belgium), Boston University (United States), University of Oxford (United Kingdom), CIBER - Centro de Investigacion Biomedica en Red (Spain), University of Edinburgh (United Kingdom), University of Washington (United States), University of Cambridge (United Kingdom), University of Washington Seattle (United States)

Services offers

Applications sectors

  • Biotechnology
  • Health / wellness
  • Education / Training
  • Science / Research

Services provided

• Prognostic biomarkers research
• Approaches for prevention of chronic diseases

Consulting services

We provide consulting services related to all our areas of expertise.

Equipments

We possess state-of-the-art scientific instruments gathered within internal and external technological platforms :
- Confocal microscope
- Electrophoresis systems Biorad Protean IEF, Protean II and GE Healthcare Ettan DaltSix
- Powerlook 3 (UMAX) black and white scanner
- Ettan DIGE fluorescence scanner (GE Healthcare)
- Biorad SELDI-TOF PCS4000 mass spectrometer
- Bio-Plex 2000 immunoanalysis system

Biological materials

• Cell lines: HEK293
• Primary cells: mesangial cells
• Caenorhabditis elegans
• Mouse models, zebrafish... (knock-out...) : RAGE-/- mice
• Large DNA and plasma libraries hosted by the Biological Resource Center of the Pasteur Institute of Lille

Ecosystem

Affiliated institutions / organisations

CHU de Lille
Inserm
University of Lille
Institut Pasteur de Lille

Equipex/EquipEx+/ESR

Doctoral schools

Regional strategic areas of activity

  • Health and Nutrition
    • Food ingredients
    • New therapeutic approaches
    • Prevention, well-being and the silver economy
  • Societal and economic transition & Risk management
    • Resilience, risk factors and fragility

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Thematics

Current thematics

  • Health and Nutrition
    • Food ingredients
    • New therapeutic approaches
    • Prevention, well-being and the silver economy
  • Societal and economic transition & Risk management
    • Resilience, risk factors and fragility
Title

Current content

Risk factors and molecular determinants of aging-related diseases
Type

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Research unit
Description

Current content

The main goal of our laboratory is to analyze, explore and understand the trends and determinants of major chronic diseases (cardiovascular and neurodegenerative) related to aging in order to propose new approaches for prevention and treatment, paving the way for personalized medicine and increased life expectancy without disability. Our laboratory is open to collaborations.
Contact informations
Contact

Current content

Contact name Email phone number
AMOUYEL Philippe philippe.amouyel@pasteur-lille.fr (+33) 3 20 87 77 10
URL

Current content

https://pasteur-lille.fr/centre-de-recherche/unites-de-recherche/facteurs-de-risque-et-determinants-moleculaires-des-maladies-liees-au-vieillissement/

Address

Current content

1 rue du professeur Calmette
Institut Pasteur de Lille
59019 LILLE
Keywords

Current content

Aging, Chronic diseases, Cardiovascular diseases, Neurodegenerative diseases, Alzheimer's disease, Physiopathology, Genomics, Bioinformatics, Big data
Our search domains
Skills

Current content

• Public Health • High-throughput genomics, bioinformatics, High Content Screening • Molecular aspects of aging pathologies • Inflammaging • Chronic diseases • Cardiovascular, cerebrovascular and metabolic diseases • Neurodegenerative diseases • Alzheimer's disease • Metabolism • Glycation • Study of membrane proteins and their post-translational modifications • Analysis of molecular interactions
Workforce

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Nombre de chercheurs :
Nombre de doctorants :
Nombre de personnel d'appui à la recherche :
Effectif total : 79
Example(s) of projects

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Example(s) of publications

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Collaborations/Partners/Scientific clients

Current content

National: University of Paris, Sorbonne University, University of Bordeaux, INSB, University of Paris Saclay, CHU Bordeaux, Hopital Universitaire Pitie-Salpetriere - APHP, CHU Strasbourg, CHU de Toulouse, University of Strasbourg International: University of London (United Kingdom), Harvard University (United States), Helmholtz Association (Germany), Erasmus University Rotterdam (Netherlands), Karolinska Institutet (Sweden), University College London (United Kingdom), University of California System (United States), Ghent University (Belgium), Boston University (United States), University of Oxford (United Kingdom), CIBER - Centro de Investigacion Biomedica en Red (Spain), University of Edinburgh (United Kingdom), University of Washington (United States), University of Cambridge (United Kingdom), University of Washington Seattle (United States)
Collaborations/Partners/Private Clients

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Services offers
Training offers

Current content

Services offers

Current content

• Prognostic biomarkers research • Approaches for prevention of chronic diseases
Consulting services

Current content

We provide consulting services related to all our areas of expertise.
Equipments
Equipements spécifiques

Current content

  • Mass spectrometer
    SELDI-TOF PCS4000/ Biorad
  • Immunoassay system
    Bio-Plex 2000/ Biorad
  • Black and white scanner
    Powerlook 3/ UMAX
  • Fluorescence scanner
    Ettan DIGE/ GE Healtcare
  • Electrophoresis system
    Protean IEF/ Biorad
  • Electrophoresis system
    Ettan DaltSix/ GE Healthcare
Ecosystem
Affiliated institutions / organisations

Current content

  • CHU de Lille
  • Inserm
  • University of Lille
  • Institut Pasteur de Lille
Établissement(s) partenaire(s)

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Unit(s) of attachment

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Groups/Networks/Federations

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Doctoral schools

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Equipex/EquipEx+/ESR

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Competitive cluster

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Regional strategic areas of activity

Current content

  • Health and Nutrition
  • Food ingredients
  • New therapeutic approaches
  • Societal and economic transition & Risk management
  • Resilience, risk factors and fragility
  • Prevention, well-being and the silver economy
Personal informations
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