• Health and Nutrition
  • Societal and economic transition & Risk management

Risk factors and molecular determinants of aging-related diseases (RID-AGE)

Research unit - U 1167


The main goal of our laboratory is to analyze, explore and understand the trends and determinants of major chronic diseases (cardiovascular and neurodegenerative) related to aging in order to propose new approaches for prevention and treatment, paving the way for personalized medicine and increased life expectancy without disability. Our laboratory is open to collaborations.


  • Philippe Amouyel




• Public Health
• High-throughput genomics, bioinformatics, High Content Screening
• Molecular aspects of aging pathologies
• Inflammaging
• Chronic diseases
• Cardiovascular, cerebrovascular and metabolic diseases
• Neurodegenerative diseases
• Alzheimer's disease
• Metabolism
• Glycation
• Study of membrane proteins and their post-translational modifications
• Analysis of molecular interactions

Collaborations/Partners/Scientific clients

University of Paris, Sorbonne University, University of Bordeaux, INSB, University of Paris Saclay, CHU Bordeaux, Hopital Universitaire Pitie-Salpetriere - APHP, CHU Strasbourg, CHU de Toulouse, University of Strasbourg

University of London (United Kingdom), Harvard University (United States), Helmholtz Association (Germany), Erasmus University Rotterdam (Netherlands), Karolinska Institutet (Sweden), University College London (United Kingdom), University of California System (United States), Ghent University (Belgium), Boston University (United States), University of Oxford (United Kingdom), CIBER - Centro de Investigacion Biomedica en Red (Spain), University of Edinburgh (United Kingdom), University of Washington (United States), University of Cambridge (United Kingdom), University of Washington Seattle (United States)

Services offers

Applications sectors

  • Biotechnology
  • Health / wellness
  • Education / Training
  • Science / Research

Services provided

• Prognostic biomarkers research
• Approaches for prevention of chronic diseases

Consulting services

We provide consulting services related to all our areas of expertise.


We possess state-of-the-art scientific instruments gathered within internal and external technological platforms :
- Confocal microscope
- Electrophoresis systems Biorad Protean IEF, Protean II and GE Healthcare Ettan DaltSix
- Powerlook 3 (UMAX) black and white scanner
- Ettan DIGE fluorescence scanner (GE Healthcare)
- Biorad SELDI-TOF PCS4000 mass spectrometer
- Bio-Plex 2000 immunoanalysis system

Biological materials

• Cell lines: HEK293
• Primary cells: mesangial cells
• Caenorhabditis elegans
• Mouse models, zebrafish... (knock-out...) : RAGE-/- mice
• Large DNA and plasma libraries hosted by the Biological Resource Center of the Pasteur Institute of Lille


Affiliated institutions / organisations


Doctoral schools

Regional strategic areas of activity

  • Health and Nutrition
    • Food ingredients
    • New therapeutic approaches
    • Prevention, well-being and the silver economy
  • Societal and economic transition & Risk management
    • Resilience, risk factors and fragility